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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Beta-lactamase inhibitor protein ： ウィキペディア英語版 Beta-lactamase inhibitor protein In molecular biology, the Beta-Lactamase Inhibitor Proteins (BLIP) are a family of proteins produced by bacterial species including ''Streptomyces''. BLIP acts as a potent inhibitor of beta-lactamases such as TEM-1, which is the most widespread resistance enzyme to penicillin antibiotics. BLIP binds competitively the surface of TEM-1 and inserting residues into the active site to make direct contacts with catalytic residues. BLIP is able to inhibit a variety of class A beta-lactamases, possibly through flexibility of its two domains. The two tandemly repeated domains of BLIP have an α2-β4 structure, the β-hairpin loop from domain 1 inserting into the active site of beta-lactamase. BLIP shows no sequence similarity with BLIP-II, even though both bind to and inhibit TEM-1. ==References== 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Beta-lactamase inhibitor protein」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.